Modeling Non-inherited Antibiotic Resistance
نویسندگان
چکیده
منابع مشابه
Modeling Non-inherited Antibiotic Resistance
A mathematical model is presented for the increase and decrease of non-inherited antibiotic resistance levels in bacteria. The model is applied to experimental data on E. coli exposed to amoxicillin or tetracyclin in different concentrations. The parameters of the model are estimated using a Monte Carlo Markov Chain method. The model accurately describes build-up and decline of antibiotic resis...
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This paper describes a stochastic implementation of Austin et al.’s (1999) model of the spread of antibiotic resistance in a population of fixed size under varying conditions of antibiotic use. The population is divided into sub-groups: individuals colonized by commensal bacteria and an uncolonized group. The colonized group is further divided according to whether the commensal bacteria are sen...
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There have been many calls for more information about the natural resistome and these have also highlighted the importance of understanding the soil resistome in the preservation of antibiotics for the treatment of infections. However, to date there have been few studies which have investigated the culturable soil resistome, which highlights the difficulties faced by microbiologists in designin...
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Antibiotic resistance is an ongoing evolutionary process that has been the concern of infectious disease specialists since antibiotic use gained popularity. Antibiotic resistance is not a concern of the public as reflected by their desire for antibiotics whenever illness occurs. Patients can and do pressure their physicians for antibiotics ; 12 million antibiotic prescriptions were filled for u...
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Antibiotic resistance genes are commonly regulated by sophisticated mechanisms that activate gene expression in response to antibiotic exposure. Growing evidence suggest that cis-acting non-coding RNAs play a major role in regulating the expression of many resistance genes, specifically those which counteract the effects of translation-inhibiting antibiotics. These ncRNAs reside in the 5'UTR of...
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ژورنال
عنوان ژورنال: Bulletin of Mathematical Biology
سال: 2012
ISSN: 0092-8240,1522-9602
DOI: 10.1007/s11538-012-9731-3